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 21/04/2012 20:42
 

New Post
 27/04/2012 15:26
 

Hi John

Is there other diagnostic criteria for narcolepsy than brigton's in use.

Is it possible to have normal polygram, normal hypocretin, abnormal MLST, latency under 1min. 4/4 REMs. And be discounted as narcoleptic.

No cataplexy (so far). Some mild cases is emerging and problem is witch is what...

Br SJ

New Post
 29/04/2012 05:49
 

Found this

http://www3.unil.ch/wpmu/eunn/about-narcolepsy/how-is-narcolepsy-diagnosed/

Now the question is: Is there a classification that says polygrafy should be abnormal.

New Post
 30/04/2012 04:47
 
 Modified By SJ  on 30/04/2012 04:47:41

Diagnostic criteria
International classification of sleep disorders (ICSD), American Academy of Sleep Medicine [1]

ICSD-1 criteria: minimal criteria for diagnosis = B plus C, or A plus D plus E plus G.

A. The patient complains of excessive daytime sleepiness (EDS) or sudden muscle weakness.

B. Recurrent daytime naps or lapses into sleep occur almost daily for at least 3 months.

C. Sudden bilateral loss of postural muscle tone occurs in association with intense emotion (cataplexy).

D. Associated features include:

1. Sleep paralysis

2. Hypnagogic hallucinations

3. Automatic behaviours

4. Disrupted major sleep episode.

E. Polysomnography (PSG) demonstrates one or more of the following:

1. Sleep latency <8 minutes

2. Rapid eye movement (REM) sleep latency <20 minutes

3. A multiple sleep latency test (MSLT) that demonstrates a mean sleep latency of <5 minutes

4. Two or more sleep-onset REM (SOREM) periods.

F. HLA typing demonstrates DQB1*0602 or DR2 positivity.

G. No medical or mental disorder accounts for the symptoms.

H. Other sleep disorders (e.g., periodic limb movement disorder or central sleep apnoea syndrome) may be present but are not the primary cause of the symptoms.

ICSD-2 criteria:

Narcolepsy with cataplexy:

EDS daily for >3 months

Definite history of cataplexy - sudden and transient episodes of loss of motor tone triggered by emotions

Diagnosis of narcolepsy should, whenever possible, be confirmed by PSG followed by MSLT, the latter showing sleep latency ≤8 minutes and ≥2 SOREMs. Alternatively, hypocretin cerebrospinal fluid levels ≤110 picograms/mL

Hypersomnia is not better explained by another sleep, neurological, mental, or medical condition, medicine or substance use.

Narcolepsy without cataplexy:

EDS daily for >3 months

Typical cataplexy is not present

Diagnosis of narcolepsy MUST be confirmed by PSG followed by MSLT, the latter showing: sleep latency ≤8 minutes and ≥2 SOREMs

Hypersomnia is not better explained by another sleep, neurological, mental or medical condition, medicine or substance use.

New Post
 01/06/2012 15:26
 

In Sweden 224 cases of narcolepsy. Parents have discovered that all are from same 12 batches (delivery units) and none of 23 other batches. If this is true there must be something extra in some vaccine deliveries...

http://svt.se/nyheter/sverige/all-narkolepsi-fran-vissa-leveranser

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