New light in Pandemrix and Narcolepsy
Markku Partinen and his team in Finland have just published a new study on the link between Narcolepsy and the vaccine given to prevent H1N1, Pandemrix. The full report in English can be read here:
Once again they show the narcolepsy appears very quickly and with quite profound symptoms. All those tested were positive for the HLA DQB1*0602 subtype. The team point out that the coverage of children in Sweden and Finland was between 67% and 80% which is far higher than other European
countries. This could explain why so many Swedish and Finnish children were found to have developed narcolepsy.
The paper mentions the use of ASO3 the adjuvant found in Pandemrix but declines to say if that was one of the causes or not. The report says;
Vaccination may have induced or accelerated already pre-existing autoimmunity leading to a rapid destruction of the hypocretin cells among genetically susceptible children and adolescents...... We cannot formally rule out the contribution of other infectious agents (H1N1, seasonal influenza, rhinovirus, streptococcal infection, or some other microbial infections) together with vaccination that could have lead to the development of
The report makes two new statements;
- That while isolated cases of narcolepsy have been discovered after children were vaccinated with something other than Pandemrix, there is no evidence of an increased risk of narcolepsy with any other vaccine.
- The adjuvant in Pandemrix is very potent and for the first time in a scientific paper they speculate that the adjuvant was so strong that it included central nervous system affection. They do remain unable to say if this systemic response caused cell damage.
Finland is now seeing a 17-fold increase in the annual incidence of narcolepsy in children. A common feature in the 54 children diagnosed was that 50'had received Pandemrix within 8 months of onset of symptoms. The report's conclusions are clear;
We consider it likely that Pandemrix vaccination contributed to the increased incidence of narcolepsy in Finland in 2010 in HLA DQB1*0602 positive children. Our observations warrant further studies on the role of different environmental factors as well as pathogenetic studies to understand how a vaccination/adjuvant and other environmental triggers can cause narcolepsy.