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Clomipramine (also referred to as clomipramine hydrochloride) is used primarily for the treatment of cataplexy.

Clomipramine is widely used as an anti-depressant. It is a "generic" drug that is produced by numerous manufacturers. Clomipramine is not licensed for the treatment of narcolepsy, but is nonetheless commonly prescribed for the treatment of cataplexy by sleep specialists (so-called "off-label prescribing").

Clomipramine is usually administered as a capsule.

Clomipramine is manufactured by several different pharmaceutical companies. There should be no difference in the efficacy of these different versions of the drug. Clomipramine capsules have various strengths.

Clomipramine - BNF

Clomipramine - Guys' Information Leaflet

Side effects

As with any medication, the drugs used to treat narcolepsy can have side-effects. These can take many forms. They may be relatively minor, such as mild headaches or a dry mouth, or much more serious, such as anxiety or depression. You should check the Patient Information Leaflet (PIL) in the packaging of your medication for more details and if you experience any of these side-effects (or any not on the PIL) you should consult your doctor or pharmacist.

You can also report side effects directly via the Yellow Card Scheme. By reporting side effects, you can help improve the safety of this medicine.