Fluoxetine (also referred to as fluoxetine hydrochloride) is used primarily for the treatment of cataplexy.

Fluoxetine is widely used as an anti-depressant. It is best known by the trade name Prozac, but is now a "generic" drug that is produced by numerous manufacturers. Fluoxetine is not licensed for the treatment of narcolepsy, but is nonetheless commonly prescribed for the treatment of cataplexy by sleep specialists (so-called "off-label prescribing").

Fluoxetine is produced in several different forms, but for the treatment of narcolepsy it is usually administered as a tablet or capsule. Tablets or capsules of fluoxetine come in several different strengths, from 10mg up to 60mg. The total daily dose is usually less than 60mg, and for the treatment of cataplexy is usually taken as a single tablet early in the day.

Fluoxetine - BNF

Fluoxetine - Guys' Information Leaflet

Side effects

As with any medication, the drugs used to treat narcolepsy can have side-effects. These can take many forms. They may be relatively minor, such as mild headaches or a dry mouth, or much more serious, such as anxiety or depression. You should check the Patient Information Leaflet (PIL) in the packaging of your medication for more details and if you experience any of these side-effects (or any not on the PIL) you should consult your doctor or pharmacist.

You can also report side effects directly via the Yellow Card Scheme. By reporting side effects, you can help improve the safety of this medicine.