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Do anti-histamines affect Pitolisant/Wakix?

Blog post
30 June 2022

We have noticed quite a few posts querying the use of anti-histamines when talking Pitolisant/Wakix.

We have referred this to the manufacturer who have referred to the wording contained in the Summary of Product Characteristics (See e.g. here: https://www.medicines.org.uk/emc/glossary ) which you will find online or in each box of medicine within the Patient Information Leaflet.

Re. Anti-histamines, the exact wording from SPC:

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Resource article

Pitolisant is a drug that is used to promote wakefulness and so reduce excessive daytime sleepiness (EDS)

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