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Solriamfetol is a "stimulant" that is used to promote wakefulness and reduce excessive daytime sleepiness.

Solriamfetol, marketed under the brand name Sunosi, is a tablet that usually comes in two different strengths: 37.5mg or 75mg. The required dose will vary from patient to patient. For some, a single tablet taken shortly after waking in the morning will be sufficient. For others, it may be necessary to increase the dose (up to 150mg per day). Sunosi can be taken with or without food and taking this medication too close to bedtime (within nine hours) could cause disruption to night-time sleep.

Solriamfetol is thought to block the reuptake of dopamine and noradrenaline from the synaptic junctions between neurons, thereby increasing the concentration of these wake-promoting neurotransmitters.

Solriamfetol - BNF

Side effects

As with any medication, the drugs used to treat narcolepsy can have side-effects. These can take many forms, including abdominal pain, anxiety, a drop in appetite, headache, irritability and nausea. You should check the Patient Information Leaflet (PIL) in the packaging of your medication for more details and if you experience any of these side-effects (or any not on the PIL) you should consult your doctor or pharmacist.

You can also report side effects directly via the Yellow Card Scheme. By reporting side effects, you can help improve the safety of this medicine.